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Vectra 3D for Dogs: Side Effects

Vectra 3D for Dogs


Safe to Use Flea Drop?

Flea drops tend to get a bad rap because a select few of them really are dangerous.

The vast majority of spot-on treatments are as safe as any other pesticide, but the problem is that it’s tough to tell which ones are OK and which ones aren’t.

That’s what we’re here for. We’re investigating each flea drop in order to determine which ones are safe and which ones you should avoid. Today we’re discussing the side effects of Vectra 3D.

Just in case you’re not sure what it is, Vectra 3D is a flea drop for dogs that’s only available by prescription. It claims to kill and repel:

  • Fleas
  • Ticks
  • Mosquitoes
  • Lice
  • Fleas
  • Mites

The active ingredients are dinotefuran, which is a neurotoxin, pyriproxyfen which is an insect growth inhibitor, and permethrin, an insecticide and repellent.

Vectra 3D Side Effects

The most common side effects of Vectra 3D are redness, irritation and/or itching at administration site. This generally goes away within a few hours, and no later than a few days after you apply it.

Some of the less common side effects of Vectra 3D include:

  • Lethargy
  • Increased verbalization
  • Seizures
  • Drooling
  • Decreased coordination
  • Diarrhea
  • Vomiting

If your dog experiences any of these side effects, you need to wash the Vectra 3D off of him and contact your vet to make sure that there’s nothing seriously wrong.

Though these side effects are rare, they can be life-threatening. Because Vectra 3D is extremely effective and these side effects are so rare, every legitimate website that I could find agreed that the product is safe for use.

For the majority of animals, Vectra 3D is a safe, effective product to use as part of your pest control program but it is a chemical that can hurt your dog if he’s sensitive to the ingredients.

Also, permethrin, one of the three ingredients, is poisonous to cats so you may want to try a different product on your dog if you have a cat.

All things considered, we give Vectra 3D a thumbs up.

If you’ve used Vectra 3D with your dog, please tell us about your experience in the comments section below.

41 Responses to “Vectra 3D for Dogs”
  1. mary says:

    Wheaten terrier had a reaction after use. It’s been 1 and a half days and he still isn’t himself. He won’t eat his treats and is very lethargic. Frontline plus failed to protect him. At a loss for what to try next. If anyone has any ideas please share.

  2. Karen Hilliard says:

    Applied Vectra 3D in the evening and was up all night. He was jerking and twitching and some scratching. Bathed him at 2:30 am AND AGAIN AT 8:30 AM Called Vet and received no help. Told to bath him. Already done. Four days later and still jerking and twitching. Up all night. What to do?

    • Carolyn says:

      This has just happened to my pup. Can you please let me know what you did to help your dog? I’m so nervous.

    • janine says:

      give him benadryl and prednisone

  3. denise macpherson says:

    We used vectra on my dog and within five hrs he became very restless and figety he kept pacing. It really concerned us. After an hour or so my husband and I bathed him with an oatmeal shampoo and rinsed him very well. I am very concerned about this product. I will call my vet in the morning.

  4. Elaine says:

    Had this product applied by a vet yesterday to a 10 year old, 7.5 pound papillion. The little dog
    got very red skin , red eyes,and cried all night yesterday & today.
    This is a horrible product and should be banned. I just washed him in dawn dish washing liquid and he seems to be calming down a little.

  5. Cindy Cox says:

    My 7 yr old great Pyrenees had a bad reaction to Vectra3D the day AFTER. She became very very restless, scratched, kept trying to get something off her that WASNT there. Very hot red skin and excessive drooling and heavy panting. I have washed her twice and given her oatmeal rinses. Have her on benedryl maximum dose 3 times a day. Also XANAX to calm her down. Vet said it had to just wear off on its own now. Buyer beware.

    • Carolyn says:

      This just happened to my pup. Can you please let me know what to expect? I feel so bad and I’m so scared for her! It’s day 2 and she is so uncomfortable. Help

  6. annomious says:

    My pug has been on vectra 3D for years now and has been doing great on it. I just switched to parastar bcuz they said it was better and the vectra at their office was discontinued and since I put parastar on him he jerks and twitches

  7. Julie says:

    I used Vectra on my 12 year old dog a few days ago. (she is an 18 lb Chihuahua/Italian Greyhound mix) She has been vomiting in the evenings but other than that, no different in behavior. I thank God she hasn’t had a more severe reaction to it and will look to find another solution to treat the flea problem. OK vet just said that’s a common side effect and should subside soon. Still will look for another option in the future for treatment of fleas.

  8. Susann kraemer says:

    Our 14 month old Golden Retriever “Jane”has had her second dose of VECTA. The last time she vomited, we attributed this to a day of swimming…and perhaps ingesting water from diving) off the pier.
    This seemed to happen again this month.I do not feel we will not be using it again.
    She did not swim this time.
    Susann kraemer

  9. Nancy says:

    I just applied Vectra to my Chorkie and he started vomiting several hours after I applied it. I was told that it would work really well and that my vet uses it for her dogs. I don’t see anymore fleas on him but I am concerned that he is now vomiting.

  10. Nancy says:

    I applied Vectra to my Chorkie and it has managed to kill the fleas but now he is vomiting. He has vomited twice now since applying Vectra to him around 4 this evening. Around 9 tonight he vomited twice.
    Is this something to be concerned about or is it normal?

  11. Heidi says:

    Same here. Gave my Min Pin a dose and the next day she started acting strange. It seemed like she was experiencing seizures or hallucinations. It was horrible. I called the vet and she informed me of those reported side effects. I gave her a bath with Dawn dish soap and within a few hours, she was ok. It was a horrifying event. We didn’t know what was wrong with Cookie

  12. Kim says:

    I have applied Vectra in the past with no problems to my Bichon until this last application. She became very restless, scratching constantly, no appetite, and her hind legs started with muscle spasms. Bathed her but still scratching and still having hind leg spasms. Will definitely never use this product again. Very dangerous in my opinion.

    • Leslie says:

      How long before your dog’s leg spasms went away?

  13. Ron says:

    Put Vectra on my 3 year old Choc. lab. He started vomiting and had diaria. As soon as I started to wash it off he felt better. I would guess the vets get a good kick back from Vectra for recommending it. Front line worked fine but I listened to my vet. STAY AWAY FROM THIS PRODUCT.

  14. Liz says:

    The fur is now growing out BROWN where the Vectra 3D was applied to my white 6 year old bichon-poodle mix dog. It looks like chocolate milk was spilled on her back. I called the company who makes Vectra, and the technician told me it is likely permanent! We are bringing her to the vet Monday. So upset!

  15. Eileen says:

    Vectra 3D killed my Jack Russell. 24 hours after applying it he started having seizures. He was totaling fine, healthy dog. Then 2 seizures 2 hours apart and 3,to one that didn’t stop, vet had to euthanize him. How can these products be out there. I contacted the company and never got a reply! They killed my dog.

  16. Cindy says:

    This product kills. Put it on my 4 year old dog & she showed no of side effects. My dog just had a we’ll check your twonweeks prior & shevwas healthy. Do not use this product. If it sounds tongood to be true….guesss what it is! This product is dangerous! I will tell everyone to not use this product on their pet. I lost my 4 year old companion & I wouldn’t wish that on my worst enemy! I followed the directions & kill my dog. My heart is breaking. She died less than 24 hours after application!

    • Diana Vacek says:

      So very sorry for the loss of your companion. I totally agree that this product is way too dangerous to be on the market.

  17. Diana Vacek says:

    To make this really short, this product is too dangerous to be on the market. Should not be applied to aging, sick or dogs taking medications. Lethal to cats so they should not be around dogs that it is put on. Caused one of my dogs to havr tremors in his tail after being applied for two days. And the vet practice where I bought it and have been taking my animals to for 14 yrs never told me about any of these things.

  18. Sara says:

    After reading all of your comments I immediately got both of my shihtzus in the bathtub. Both had been vomiting, the smallest one wouldn’t stop barking. I hope they’ll be ok now. I’m throwing that stuff away!!

  19. laurie says:

    i have used vectr3d for 2 months dogs continue to have fleas. very expensive for the results are not seen . can’t find a product that works on fleas. my smaller dog is sleeping all the time.

  20. Michael says:

    I used this the first time last month, so far no problem. I can’t tell you how it works on fleas or ticks yet, as it’s still a cold winter here. I have a Golden Retriever. I have seen in some topicals, that they caution people with toy dog breeds. I am not sure, but it is very sad to hear all of the stories on here, it breaks my heart. All I can say, is that Frontline, and I am sure that biospot and anything from hartz has made dogs very sick and some have even died. We need to find a better way to fights the fleas and ticks. So be careful when saying a product should not be out, as every dog is different and reacts differently, though I would feel the same way if I was in your shoes. It’s just like human medicine, what works well for others to help them heal, or get better, has killed others. It’s just a terrible thing when it happens and there is no way to know, if one topical or another will make your pet sick. I think the key is to watch them, and at the first sight of any problems, call your vet, and it seems that people recommend, giving them a bath with dish soap to get the topical oils off of them as soon as possible.

  21. Jim Schwindt says:

    We have a 4 year old Jack Russell. When we put on and him for several weeks after we would scratch either of his front legs on the rear side, (rib cage area), and 100% of the time he goes into a bizarre state where his mouth gets drawn out as though frowning and his body gets tight, with similar to seizure like reaction. WE WILL NOT USE AGAIN.

  22. Mandy says:

    I put this on my 3 dogs. One is a 14 year old jack Russell mix and the other 2 are a 4 and 3 year old dachshund. One dachshund is on anti itch medication for allergies so he isn’t having any problems. But the other 2 are constantly scratching themselves and licking themselves so much. They are miserable. I will not be using vectra in the future I will stick to trifexis.

  23. Becky says:

    We put it on our 9 yr old rescue dog. He has been acting so strange. He acts as if he is afraid to go outside, sleeps a lot, just wants to sit next to us.

  24. Alex says:

    This is the second month I used it on my dog. Not only is he still scratching, I assume due to the fleas, but also twitching in one ear and vomiting randomly. The first time I thought it was a fluke, but everything keeps happening again. I’m giving him a bath to get that stuff off! And it’s so expensive! Never again..

  25. Carol says:

    Our dog has been getting Vectra for a year. We thought his allergies were related to food but low and behold we have the dog on dermatology diet and he was doing well. Put the Vectra for the month on and Dog is itchy as all get out. He vomited twice. He has been super vocal and we see that that too is a less reported side effect.
    Called vet took dog to groomer for dawn dish soap bath, right now washing all bedding.
    Do you think this is really all Vectra?

  26. Frederica Batchelor says:

    Have used Vectra on my 8 year old Old English sheepdog for over a year with no side effects. This month, the day after applying Vectra she started restlessly rubbing her head (eyes ears and muzzle) on both sides and snapping at her hind end as though something was biting her. Called vet who said to start giving her Benadryl 2 – 3 x a day and if it got worse to wash her in Dawn. I don’t understand how this reaction is triggered. A shame because product worked well particularly for ticks in this area.

  27. Gill Kent says:

    This needs banning immediately. Used it for the first time on my beautiful border terrier. Her reaction was scary and upsetting. Up all night pacing. Whipping her head from side to side as if she was riddled with fleas. Her back legs were wobbly. Very anxious. Didn’t eat was lethargic when she wasn’t whipping her head round and pacing. Excessive rolling on the carpet and grass as if she had fleas. It took nearly a week before she was back to her usual self after another hefty vet bill of steroids and antihistamines.
    Do not risk using this. It’s not worth putting you and you dog through so much distress.

  28. Rick says:

    My Labrador seized multiple times on the 5th day after application, and died. She was a little more than 2 months short of 12 years old. But the way she died was no fun and I got to watch. She had been experiencing unusual exhaustion symptoms at least a week before the application so something else was going on. But I felt like something was strange after application and I had never had problems with Vectra before, but I hadn’t applied it since last year. She lost power in her hind legs gradually then all 4 quite near the seizing. I don’t know if this started after the Vectra or not. I just hope they are unconnected, but I fear they may be.

  29. Bob M says:

    We applied Vectra 3d one evening to our Pomeranian and the next day he was highly anxious, jittery, extremely agitated and just wanted to hide under anything. He slowly is improving back to normal and we will not use this product again.

  30. James H says:

    I got a free sample of Vectra 3d from my local vetenarian last month and decided to use it because the prescription medicine Comfortis made my malti-poo sick and he threw it all up (this was a month ago, I didn’t administer both medications at the same time).So, this afternoon I put on Vectra 3d from the back of his neck down his back to the beginning of his tail. An hour or so I noticed my dog starting acting strange. He kept trying to make himself comfortable, getting up and scratching and laying him down and soon as he laid down he would get up and do the same thing. Almost like a restless sleeper. I had him laying on my lap and I noticed that he started breathing very shallow breaths as he was resting. Around 7:30 PM I ran into this information and washed it off him with some dish soap (regular Blue Dawn). He is still experiencing the same restlessness. I will take him down to the Vet first thing in the morning because I just feel that I made a horrible mistake. He is only 2 years old and I would just be devastated if anything happened to him because of what I gave him. I am very surprised that such a well known veterinarian would give this flea pesticide when it has so many issues. I definitely will not blindly trust the veterinarian and seek other more natural and safe flea treatments.

  31. Nancy says:

    We applied Vectra to our dogs and within 24 hours our female experienced lack of appetite, weird behavior.n we bathed her immediately and she was K. However, our ale has experienced a bloody sore which has been oozing for several days. Our Vet seemed concerned, but gave us a dermatological application to apply to the “wound”. But did not even look at the wound. Hopefully this will have no bad after effects. we will not be using this again

  32. Veronica says:

    I am very disappointed that my vet would recommend this product for my jack russel mix, she is already being treated for focal seizures. I put Vectra on her and within hours her symptoms were magnified dramatically. She couldn’t walk anywhere, lay down without her head whipping around and biting the air, her back legs kicking, she would rub against all furniture & walls. You could see she was miserable! I bathed her with dawn dish soap, gave her some CBD biscuits, her seizure meds and a Benadryl. She was able to get some rest after all of that, totally drugged but could sleep. I did the same thing the next day. How many days will it take to wear off? I clearly need to find a safer option

  33. Henry Hudson says:

    I recently applied Vectra 3D to my Sheltie’s back area and it caused his tail to stick up in the air continuously now for 4 days.

  34. My 2 Shih Tzu became very ill after application. Within 3 hours they were vomiting,had diarrhea, drooling, lethargy and restless. I don’t recommend Vectra to any animal and I was not informed on the box or by my vet that it could be harmful to Shih Tzu and small dogs!

  35. Kandie Moore says:

    We gave Vectra3D to our 2year old Lhasa Apso. He now has no balance when he walks he falls..His body rocks back and forth..His head rocks constantly Like a bobble head.. He does still eat and drinks and tries to play. It’s been 7 days now and NO sign of change.. This product my kill my dog!!

  36. David Snelling says:

    This product is the only change to my dogs every day routine..my dog now wobbles and falls..his eyes are dazed and if he isn’t sure what’s happening to him…before the application of this product Vectra3D my 2 year old 10 pound dog was so playful and alert and fast when running..now it’s as he had a stroke! Please, I implore you, do NOT USE THIS PRODUCT ON ANY PET UNLESS YOU ARE PREPARED TO LET IT DIE!!!! PLEASE DO NOT USE IT!!!

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