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Trifexis Chewable Flea Tablets for Dogs Review

Trifexis Chewable Flea Tablets for Dogs Review


As much as you want to protect your beloved pet from annoying fleas and ticks, they happen to find a way in sometimes; the problem is getting rid of them.

A flea pill is a good start but your vet has several options. Which one is the best?

Let’s examine how Trifexis (spinosad + miblemycin oxime) chewable tablets fare for flea and worm removal.

Company claims

Trifexis is a chewable tablet that kills fleas and prevents infestations. According to information available on the company’s website, Trifexis can also be used for treating and controlling hookworms, roundworms, whipworms. The tablets also prevent heartworm disease caused by mosquitoes.

Heartworm disease can be fatal for dogs if not treated. While Trifexis does not kill heartworms in case of sick dogs, it can be useful in preventing the disease.

Trifexis can be used to control –

  • Fleas
  • Intestinal worms

The tablets not only kill existing fleas and worms, but they also prevent future infestation. It has been reported that Trifexis starts killing fleas within 30 minutes of taking the tablet and kills most fleas within 4 hours.

How it works

Trifexis works by killing fleas before they can lay eggs. It also treats intestinal infections by killing parasites.

Trifexis comes in multiple options depending on the weight of your dog. For dogs between 5 and 10 lbs, Trifexis has the following ingredients –

  • 140mg Spinosad
  • 2.3mg Milbemycin oxime

Spinosad is a highly active insecticide that is known to kill adult insects by causing hyperexcitation of the nervous system. Spinosad causes disruption of acetylcholine neurotransmission.

Spinosad is a natural product with low toxicity and good environmental profile.

Milbemycin oxime is a parasitic drug that causes death by hyper-polarization of cells.

Usage information

Trifexis comes in the form of beef flavored chewable tablets that can be mixed with food or given as a treat. It should be used for adult dogs and puppies older than 8 weeks and with a body weight of more than 5 lbs.

The tablets should be given once a month throughout the year, or as recommended by the veterinarian.

Avoid giving Trifexis to an epileptic dog.

Trifexis is available online, over the counter and through any veterinary clinic.

Product warnings and side effects

Effects of Trifexis on pregnant or breeding animals haven’t been evaluated. Consult with your veterinarian before administering Trifexis to a pregnant female or a breeding male/female.

Trifexis is known to cause vomiting in some dogs. Puppies under 14 weeks old may have higher occurrences of vomiting.

Other side effects include itching, inflammation of skin, diarrhea, and decreased appetite.

High doses of Trifexis may cause stupor, tremors, and ataxia.

What Are Users Saying?

Most users really like Trifexis; in fact many users say that it’s the best flea product that they’ve ever used. There were a few scattered reports of vomiting but some users suggested that they’ve found it helpful to give the pill at mealtime in order to reduce the chance of nausea. There were a few users who reported that the pill didn’t work but since all dogs are different and heavy flea infestations require more than a single treatment, this is probably to be expected.

Final Word

Trifexis may cause vomiting in some dogs so it may be a good idea to give it with food. That being said, most people using Trifexis have been happy with the results they’ve seen and we give it a solid thumbs up.

Trifexis gets a thumbs up from us.

If you’ve used Trifexis, let us know how you liked it in the comments section below.

7 Responses to “Trifexis Chewable Flea Tablets for Dogs Review”
  1. S Onorato says:

    Yes I found this to be the best product for my Maltese. She has not had any fleas for over 2 years and all her heart worm tests have come back negative,while using Trifexis. She also has not experienced any of the side effects. I highly recommend this product.

  2. jenna says:

    One day I noticed that my poor girl sasha couldn’t stop itching so I checked her body & found flees I immediately gave her pet armor for flees & it didn’t work.so I called her doctor & they said to try frontline so I did,at first it seemed to be working but,then the flees got worse.I gave her 2 different flee meds,flee shampoo,flee powder etc nothing happened so,I called her dr again & they recommended trifexis I gave it to her yesterday & over night they we’re almost all gone.I still see a couple but,it seems to be working & best part about trifexis is it’s not only for flees but,also for heartworms,hookworms,intestinal works etc for $21 bucks it’s we’ll worth it.finally my dog isn’t constantly itching ty trifexis!! :)

  3. sarah says:

    Trifexis has a warning now because there are issues with dogs dying after using it.

  4. Jean B. says:

    I have been giving Trifexis to my four dogs — two large golden retrievers and two small poms. I noticed my poms have been having seizures — like they are susddenly frozen and cannot move. Plus one always vomits the next day. For my large dogs, one appears to be “in space”, and gets very sluggish and you can tell she is not feeling well cause all she wants to do it lay down. And she too, vomits many hours later. It has scared me and I have taken them off the drug today after reading so many other bad reviews that it killed their pets. I do not want to kill my pet. Will look into other preventive measures.

  5. Jill G says:

    I have 3 Chaweenie puppies…8 to 10 lbs each. I give Trefexis before bedtime covered in peanut butter they swallow it before knowing what it was!I guess because they are going to bed I’ve never had a problem…I started them as baby pups…no vomiting…no issues…works like a charm…love it!

  6. Jill G says:

    oh forgot…my 3 pups are now 2yrs old! Very healthy!

  7. Geraldine Thibodeaux says:

    I unsed Trefexis bor my Yorkie and loved it. It was 1 pill each month. The vets here don’t carry this product any more. They have Bravecto which I am not crazy about. Why did the vets quit carrying the Trefexis product.

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