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Revolution Vs Frontline Plus for Dogs and Cats

Revolution Vs Frontline Plus

Which Flea Drop is Best for Your Pet?


In the search for a good flea drop, you’ve probably realized that there are more than a dozen options, but which one is right for your pet?

The answer lies mainly in two areas: which ones actually work, and which ones meet your particular needs.

Throughout the following paragraphs, we’re going to compare two of the top spot-on flea treatments, Revolution and Frontline Plus, so that you can make an informed decision about your flea prevention.

What Do They Do?

To begin, Revolution is available only from your vet while Frontline Plus is available over the counter. They also have different ingredients, though the functions are similar.

Revolution’s active ingredient is selamectin, a neurotoxin that kills adult parasites and keeps the eggs from hatching. It’s effective against fleas, American dog ticks, mites, heartworms, roundworms and hookworms.

Unlike many other flea drops, Revolution is purportedly odorless, non-greasy, and waterproof after just 2 hours. You can use it on dogs and cats 8 weeks of age and older and you simply squeeze it onto the skin at the back of the neck area.

Frontline Plus has 2 active ingredients: fipronil and S-methoprene. Fipronil is a neurotoxin that acts kills biting parasites such as fleas, ticks and mites. S-methoprene is an insect growth inhibitor that prevents larvae from developing into adult fleas. Between the two, the ingredients in Frontline Plus protect your pet from a variety of biting insects, but not internal parasites such as heartworms or intestinal worms.

There are some resistant strains of fleas in places such as Florida and Georgia that don’t respond to the ingredients in Frontline Plus, so you should talk to your vet about that if you’re in those areas.

Side Effects

The most common side effect of both Revolution and Frontline Plus is minor skin irritation at the administration site but that usually clears up within a day or so. The fipronil in Frontline Plus is mildly toxic to other animals and fish so you should use caution when applying it. Don’t let the kids touch it and wear gloves when you put it on.

If you opt to use Revolution, you need to have your dog or cat tested for heartworms prior to administration because if your pet is infected, the medication can cause shock-like reactions and can even kill them.


We like the fact that Revolution is a broad-spectrum flea drop that protects your pet from both biting insects and internal parasites. Also, if you live in Florida or Georgia, Frontline Plus may not be as effective for you as it will be for other people. Throw in the fact that Revolution is safer, odorless and non-greasy and it wins hands-down for us for folks who are looking for all-in-one parasite control.

If you’re already using an anti-parasitic that you’re happy with, then Frontline Plus may work just fine for you. It’s all about what your pest control needs are.

Revolution is only available from your vet but to find great deals on Frontline Plus, click here.

If you’ve tried either Revolution or Frontline Plus or, better yet both, please tell us about your experience in the comments section below.

2 Responses to “Revolution Vs Frontline Plus”
  1. bk says:

    Revolution does not work on my cats. Even though they are indoor only, fleas, as well as mosquitoes, in my part of the county (Central Texas) are endemic. My vet keeps pushing Revolution because of the heartworm prevention. But every time I break down and get a ‘scrip for Revolution my cats itch and itch and eventually the house gets infested.

    I’ve found Frontline to be better at fleas.

  2. Denise says:

    I live in south Florida. Revolution works better than frontline/frontline plus for my cats.

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