Frontline Plus for Dogs Review

Flea and Tick Protection All Month Long

Frontline Plus side effects

It can be difficult to keep your dog flea and tick free. Dogs have to go outside several times a day and in warm weather, fleas and ticks are everywhere.

It’s difficult to treat your dog for fleas after they are infected because you have to kill the adults and the eggs on the dog, in the carpet and in their bedding, so it’s best to avoid them at all costs. Frontline Plus may be just the product you need to help you do that.

Company Claims

Frontline Plus for Dogs offers a solution to your flea problems by killing all of the fleas that come into contact with your pet during the next 30 days. It also kills adult ticks that try to attach themselves to your dogs.

Since fleas cannot breed without animal blood, they have to jump onto your dog to complete their life cycle. This product kills the fleas as soon as they try to bite your dog, preventing them from laying eggs.

Active Ingredients

Frontline Plus for Dogs has two active ingredients:

  • Fipronil
  • (S)-methoprene

How these ingredients work

Fipronil works by blocking the communication between the brain and the body of the insect. This causes hyper-excitability (similar to high blood pressure in humans) and eventual death.

This is the ingredient that kills the adult fleas and ticks before they have a chance to bite your dog. They lose the ability to control their heads, preventing them from biting your pet, which they need to survive and breed.

Methoprene is a growth regulator that mimics juvenile hormones in insect eggs and pupa. It prevents these from completing the life cycle to adult and breaks the cycle completely in fleas. It is also non-toxic to humans and is used to treat drinking water to prevent the growth of mosquito larvae.

Usage Information

Once a month you apply a single packet of Frontline Plus for Dogs onto your dogs neck. It should be applied at the base of the spine and directly to the skin, so make sure you part the hair all of the way down, until you actually see the skin of your dog. This is especially important with longer hair breeds, such as collies and sheep dogs. If the product is not applied to the skin, then it will not enter the sweat glands and remain active for the full 30 days.


There have been no reports of allergic reactions in dogs when using this product. About one in one hundred dogs seem to have a minor skin reaction to it, but this normally clears up within 24 hours.

There are resistant strands of fleas, especially in Florida and Georgia, which do not seem to respond to the pesticides in products like this one. If you live in these states, please check with your veterinarian to see if the fleas in your area are resistant. If they are, then you may want to choose an alternative product for your dog.

Side Effects and Precautions

The only precaution noted for Frontline Plus for Dogs was that you should not use the product until your dog is at least 8 weeks old. You should also keep your pet away from open water for 24 hours, which includes allowing them to go outside and play in the rain.

When you first use the product, you may see more fleas appear on your animal, but this is not an indication that the product did not work. Fleas move to the surface of the hair when they are dying, so they will migrate away from the skin within the first 4 hours after application and then should be gone within 12 hours.

If the infestation continues, you may have a resistant strand of flea and should consult with your veterinarian.


We can feel confident recommending Frontline Plus for Dogs because it seems to be very effective on most dogs. It does have a minor problem because of the resistance of some flea colonies, but this is only prevalent in areas such as Florida and Georgia. Thumbs up!

To find a good deal online for Frontline Plus, click here!

If you’ve used Frontline Plus, please tell us about your experience in the comments section below.

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