Frontline Plus for Cats Review

Effective Flea and Tick Control for Cats?


It can be difficult to control fleas and ticks on cats because they’re not exactly fond of baths.

Frontline Plus offers an alternative by offering a topical treatment that can be applied directly to the skin of your cat.

This eliminates the discomfort of bathing a cat and offers longer protection than most shampoos and powders.

Company Claims

Frontline Plus for Cats works by disrupting the life cycle of the fleas and prevents ticks from surviving on the skin long enough to embed into your cat. It uses two separate ingredients, one of which works by killing the adult animals and the second interrupts the life cycle of any eggs, preventing them from hatching.

It is known for its low incident of allergic reactions in most cats. It is stored in the oil glands of your cat, making it one of the longest lasting topical treatments for fleas and ticks.

Active Ingredients

Frontline Plus for Cats has two active ingredients:

  • Fipronil
  • (S)-methoprene

How Does Frontline Plus for Cats Work?

Fipronil works by blocking the communication between the brain and the body of the insect. This causes hyper-excitability (similar to high blood pressure in humans) and eventual death.

This is the ingredient that kills the adult fleas and ticks before they have a chance to bite your cat. They lose the ability to control their heads, preventing them from drawing blood from your pet, which they need to survive and breed.

Methoprene is a growth regulator that mimics juvenile hormones in insect eggs and pupa. It prevents these from completing the life cycle to adult and breaks the cycle completely in fleas. It is also non-toxic to humans and is used to treat drinking water to prevent the growth of mosquito larvae.

Usage Information

Once per month, you would apply one packet of Frontline Plus for Cats to the skin on the back of your cat’s neck. The hair should be parted until you can actually see the skin. The entire packet should be applied in one location and you should avoid washing your pet for 24 hours after application.

What Are Users Saying About Frontline Plus?

There have been no reports of side effects when using Frontline Plus for Cats but there have been some issues in certain areas. Most people enjoy using this product because it is easy to apply and does not have an adverse effect on their cat’s behavior or health.

Some fleas become resistant to certain pesticides over time and this has occurred in several southern states. If you use the product and your pet is still infested with live fleas, then you may have to speak to your veterinarian about what works in your area.

Side Effects and Precautions

The only precaution noted for Frontline Plus for Cats was that you should not use the product until your cat is at least 8 weeks old. You should also keep your pet away from open water for 24 hours, which is pretty simple when dealing with cats.

When you first use the product, you may see more fleas appear on your animal, but this is not an indication that the product did not work. Fleas move to the surface of the hair when they are dying, so they will migrate away from the skin within the first 4 hours after application and then should be gone within 12 hours. If the infestation continues, you may have a resistant strand of flea and should consult with your veterinarian.


We have no problem recommending Frontline Plus for Cats because of its low toxicity and its overall effectiveness. There appear to be some problems with resistant fleas but they only appear in certain states. The largest number of resistant infestation appear to be in Florida and Georgia, so if you live in these two states, you may want to consider another product before you make an investment in Frontline Plus.

To find a good deal on Frontline Plus for Cats, click here.

If you’ve tried Frontline Plus for cats, please tell us about your experience in the comments section below.

One Response to “Frontline Plus for Cats Review”
  1. Jerry says:

    What happens if cat moves during applications, solution dispensed to one side of neck. Cat has been able to lick coat there, and now seems to be bleeding from nose. Should I be concerned?

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