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Advantix II Vs Vectra 3d for Dogs

Advantix II Vs Vectra 3d


The War of Best Flea Drops Rages On

It seems as if there are a million different types of flea drops available on the market but which one is the best for your dog?

Today we’re going to take a look at two of the top products available only from your veterinarian: Advantix II and Vectra 3D to decide which product is best for your pet.

What Do They Do?

Both products are spot-on treatments that are applied at the base of the neck in order to fight fleas and other biting parasites. They both work for up to 30 days.

The active ingredients in Vectra 3D are:

  • Dinotefuran, a neurotoxin
  • Pyriproxyfen, an insect growth inhibitor
  • Permethrin, a neurotoxin and insect repellant

Vectra claims to kill fleas, ticks, mosquitoes, biting flies, sand flies, lice and mites, excluding mange mites.

The active ingredients in Advantix II are:

  • Imidacloprid, which is a neurotoxin
  • Permethrin
  • Pyriproxyfen

As you can see, the two products share two of their ingredients. Advantix II kills and repels fleas, ticks and mosquitoes, kills lice and repels biting flies.

Side Effects and Warnings

The most important warning attached to both of these products is that permethrin is toxic to cats and can even kill them so if you have cats, you need to keep them away from your dogs until the flea meds are dry. Obviously, you can’t use either of these on cats either.

Advantix II and Vectra 3D share the most common side effect, which is rash, itching, or irritation at the site of administration. If it gets too severe or lasts for more than a day or two, just wash your dog with dish detergent. If it persists after that, you may want to call your vet.

The two flea drops share the exact same rare side effects as well. The ones listed below are extremely uncommon but could happen.

  • Lethargy
  • Hyperactivity
  • Drooling
  • Shaking
  • Poor Coordination
  • Excess vocalization

If your pet exhibits any of these symptoms, you should wash off the medication and contact your veterinarian immediately.

Final Word

Advantix II and Vectra 3D are both recognized as safe to use on your dog but due to the permethrin cannot be used on cats.

They carry equal risks and the only discernible difference is that Vectra 3D claims to kill mites as well. The two different neurotoxins act in essentially the same way and one really isn’t recommended as better than the other.

In this instance, we simply recommend that you choose the product that your vet recommends.

If you’ve used either of these products, please tell us about your experience in the comments section below.

9 Responses to “Advantix II Vs Vectra 3d”
  1. Jovana says:

    I’ve been using vectra 3d on my maltipoo for 6 months because its what my vet recommended. Every month it seems after a week or two he starts scratching and has fleas. When I phoned my vet’s office they asked if I was using “soap free” shampoo when I bathed him and if I was I was washing it off…. I read all the paper work in the package of vectra 3d and nowhere did it say to use soap free shampoo when bathing. Wish they would have told me when I purchased or stated on package inserts. Wasted money for sure! They did say it was ok to reapply since it was washed off.

  2. Eyssa says:

    I have used this on my 7lb Maltese and nothing keeps fleas away better! I can literally see them jump on my dog (as he’s white) and then jump right back off!
    The only thing that concerns me is he gets hyperactive after I apply it. I try to spread the dose in 3 sections so it doesn’t irritate him so much in one spot. Maybe that’s causing the problem and will try this month to put it all on his neck.
    If you have any suggestions I would love them!

    • Cameron says:


      I am considering a method that may be helpful as well for you. My dog gets a bit hyper as well. I thought perhaps a 1/4 dose today and each week a 1/4 dose to break it up. A little more work and not a full dose that may irritate them. I know companies want to sell us easy options but perhaps we are to easily sold. I didn’t have a pet for two years because it can be so time consuming. I a great dog now and want to really be the best doggie daddy I can.

      Best of luck and never be afraid to think outside the box.

  3. Sue says:

    I have been using Vectra 3D for a few years now and it has always worked quite well until this summer. I just gave my 4 dogs their August treatment and they are biting and scratching themselves raw. I do not bathe them so I know that it cannot be used as an excuse as to why it is not working. They are bigger dogs so I paid over $20 per tube so I can’t afford to try something else. I will be switching over to something else for their next treatment. I have to find something to use on them that will be safe and will ease their discomfort.

  4. chad from NY says:

    calling the vectra 3d phone number does no good they never call back to answer any question you have, useless switching products.

  5. Jim from WA says:

    I’ve been using K9 Advantix II for four years on my two dogs, a 60-lb lab and a 30-lb terrier, with excellent results. We spend all winter at western WA home with fenced yard — few or no fleas or ticks in the lawn, so minimal need for meds. But from mid-Apr to mid-Nov, we alternate — one week at our western WA home, then one or two weeks at our eastern WA property (LOTS of ticks & fleas), so we need heavy protection. Like I said, K9 Advantix II has kept the dogs (and therefore our homes) flea and tick free, with no discernible ill-effects. To save money, I’ve bought the super-size dose and divided it ⅓ to the little guy, ⅔ to the lab. This has worked great, saves $, and the dosages applied are the same as the two smaller separate dosages.

    • Cameron says:


      You are a man’s man. I love the ratio mix you use. I have been doing for our 2 dogs forever(since WE can buy it anyway).
      Cudo’s from a fellow smartypants : }

  6. Karen says:

    Our 2 malamutes were on Vectra 3D and had absolutely no skin or hair issues. Our Vet switched them to Advantix ll and the time is way to close not to notice they have both been miserable for the last few years they have been treated with injections for itching prednisone and antibiotics for secondary infections from biting and scratching. They have lost a lot of hair. When they were on Vectra 3D their skin and coats were beautiful no itching no scratching. From my research the difference is that Vectra 3D claims to kill mites and Advantix ll does not going back to Vectra 3D and praying this works. They are miserable they have been bathed , groomed topical treatments you name it even a food switch for food allergic dogs. They are not from the same litter either. So it has to be something common to both. This is too much of coincidence just hoping!

    • Cameron says:

      Hi Karen,

      Change things slowly or you may get varied results. Do what worked best and change from there. It was good then it wasn’t. Go back what was and if change needs to happens go slowly. Food first or meds first and give a ~30 period to see. Our bodies adapt quickly but we have to observe one variation at a time as in a laboratory because life is OUR laboratory(unfortunately;)

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