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Advantix II Vs Frontline Plus for Dogs: Effectiveness and Safety

Advantix II Vs Frontline Plus

Which Flea Drop is Right for Your Dog?


Are you trying to figure out which spot-on flea treatment is best for your dog?

With all of your options, it’s no wonder that you’re having problems, but we’re here to help.

We’re going to compare Advantix II and Frontline Plus, two of the leading flea drops available over the counter today.

What Do They Do?

To understand what these flea drops can do, you need to know what the ingredients are and how they work.

Advantix has three active ingredients. Iimidacloprid, a neurotoxin that kills fleas by causing extreme excitability, paralysis, then death. Permethrin is a synthetic neurotoxin that acts similarly and pyriproxyfen is and insect growth inhibitor that prevents eggs and larvae from maturing into adult fleas.

Note that permethrin is dangerous and even lethal to cats. If you use Advantix II on your dog and have cats, you need to keep them separated until the drops dry!

Frontline has only two ingredients: fipronil, which is a neurotoxin that causes paralysis and death, and S-methoprene, an insect growth regulator that keeps larvae from developing into adults.

Both Advantix II and Frontline plus kill adult fleas, larvae, eggs, ticks, chewing lice with minimal risk of irritation for up to a month. Advantix II also deters mosquitoes and biting flies.


We’re a bit mixed on this one because, though Advantix II takes care of mosquitos and biting flies, it also has permethrin in it and has received some tough reviews online. Frontline Plus has better reviews so if you have cats and/or don’t need mosquito protection, we’d recommend Frontline Plus over Advantix II. If mosquitoes or biting flies are a real issue and you don’t have cats, then go with Advantix II.

To find a great deal on Frontline Plus, click here. To find Advantix II at better prices than you’d find at the store, click here.

If you’ve tried Frontline Plus or Advantix II or, even better, both of them, please tell us about your experience in the comments section below.

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