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Advantage Multi for Dogs Review: Effectiveness & Safety

Advantage Multi for Dogs Review (now known as Advocate)


A Flea Drop that Kills Worms, Too?

Dog owners have to worry about their pets coming into contact with dangerous parasites all the time.

This is why we’re reviewing Advantage Multi for Dogs; it claims to be much more than a flea medicine. We will explore the company claims, the active ingredients, and check out some comments made by others who have used the product.

Company Claims

Advantage Multi for Dogs can help control fleas and prevent an infestation of hookworms, roundworms, and whipworms. It is a topical treatment developed by Bayer that is only available with a prescription from your veterinarian.

Advantage Multi is applied once a month to dogs over 7 weeks old and can prevent all of the above parasites for a full 30 days.

Active Ingredients

The two active ingredients for Advantage II for Dogs are:

  • Imidacloprid
  • Moxidectin

How Does Advantage Multi Work?

Imidacloprid acts as a neurotoxin in insects, causing them to lose control of their central nervous system. This leads to paralysis and eventual death. It is also slightly toxic to mammals and should only be used on the outside of your dog. It is one of the most widely used insecticides in the world but it is considered moderately toxic when ingested orally.

Moxidectin is only used to kill parasites, such as intestinal worms. It functions by stopping the neurotransmission within the worm, leading to paralysis and death. It doesn’t appear to have any harmful effects on humans and is benign in most other mammals. There have been no conclusive tests regarding the treatment on pregnant or lactating dogs.

Usage Information

Advantage Multi for Dogs should be applied to the back of the neck once a month. The application should be made directly to the skin on the back of the dog’s neck. Since this product is only available with a prescription, your veterinarian will inform you if any change needs to be made in this dosing schedule.

You should prevent your dog from licking the treated area for at least 30 minutes and not let them around untreated dogs for the same period of time.

What Are Users Saying?

Some owners have reported that their dogs experienced lethargy and restlessness. They would lay around for a few days and not seem to go to sleep. It is unknown if this was caused by an irritation of the skin or an actual adverse reaction to the medication.

If your pet is already infested with worms, then you may need a deworming treatment before you apply this medication. It is only for the prevention of future infections and does not remove current infestations.

The only other concern was the cost of the medication because it is higher than most other topical treatments. The reason for the higher price seems to be the active ingredient that prevents parasitical worms. Otherwise, it is comparable to other, similar preventative measures.

Side Effects and Precautions

The only side effect seems to be irritation and sensitivity in some animals. If your pet shows any adverse symptoms, then you should contact your veterinarian immediately and wash the treated area with warm water and a pet-safe shampoo.

Here is a list of the possible side effects and what to watch for in your dog:

  • Facial swelling
  • Hives
  • Scratching
  • Diarrhea
  • Vomiting
  • Shock
  • Seizures
  • Pale gums
  • Cold limbs
  • Coma


There are a number of possible side effects with this medication, but they are considered rare. If you are worried about your dog being exposed to hookworms, roundworms, and whipworms, then your veterinarian may recommend Advantage Multi for Dogs.

If your only complaint is exposure to fleas, then there are other, safer, medications available that work just as well without the added expense of a prescription and visit to the vet.

If, however, you’d like to fight a multitude of parasites, then Advantage Multi for Dogs (now known as Advocate) may be just the product that you’re looking for.

To find great deals on Advantage Multi for Dogs, click here.

If you’ve used Advantage Multi, please tell us about your experience in the comments section below.

7 Responses to “Advantage Multi for Dogs Review (now known as Advocate)”
  1. Melanie Brink says:

    A few hours after and a day or two after using Advantage Multi my two poodles, Bentley 10 months and Benjie 4 months urin smells like hair perm solution. Is this common ?

    • Theresa says:

      I couldn’t find this particular side effect in any of the literature or on any other user sites, so I’d recommend calling your vet about it. Did you make any other changes? Let us know how this works for you.

    • Jackie says:

      I noticed something similar. I gave the medication to my chihuahua and my dachshund and their urine had a remarkably potent stench for about 24 hours. After that, the smell returned to normal.

  2. Naomi Vargas says:

    I’m giving the medication to two small dogs and it only lasts for about two weeks on both before fleas are biting them and they are both scratching. When I get the fleas using a comb they have blood in them. I’ve told the vet about this and he’s told I am not applying it correctly. He applied it and the same thing happened. I do bathe them several times a month, but I don’t think this should affect it since they are not bathed 3 days before or after the drops. What could be causing this?

    • Chrissy says:

      Yes -giving baths can effect the flea medication. Since it is a topical at rest on top of the skin in the oils. Your shampoo needs to be soap free also called tearless. I’ve used advantage multi for the past 10 years I never had an issue. And that’s in Alabama where the fleas are horrendous. We have to use it all year round down here.

  3. Bull says:

    So-called articles like this should be illegal. “What Are Users Saying? Some owners…” What? 3 owners? 5 owners? You did no scientific study on decent size control groups with this treatment versus others to have any kind of, “Conclusion…”.

    This was just a completely bogus so-called article to get people to this site to spend money.

    BOYCOTT this site!

  4. Bull says:

    NOTE: Never use dog treatment on cats, and visa versa!

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