Advantage Multi for Cats Review

A Flea Drop that Kills Worms, Too?


That’s why we’ve collected information from a variety of sources in order to determine of Advantage Multi for Cats is the safe, effective treatment that you’re looking for.

Company Claims

Advantage Multi for Cats can help prevent flea infestations and protect your cat from a variety of other parasites.

Advantage Multi can help prevent heartworms, hookworms, roundworms and ear mites. It does this through the use of two different insecticides that work together to prevent infestation from these parasites.

Active Ingredients

The two active ingredients for Advantage II for Cats are:

  • Imidacloprid
  • Moxidectin

How Does Advantage Multi for Cats Work?

Imidacloprid acts as a neurotoxin in insects, causing them to lose control of their central nervous system. This leads to paralysis and eventual death. It is also slightly toxic to mammals and should only be used on the outside of your cat. It can be dangerous if ingested orally and should only be used as a topical treatment.

Moxidectin is only used to kill parasites, such as intestinal worms. It functions by stopping the neurotransmission within the worm, leading to paralysis and death. It does not appear to have any harmful effects on humans and is benign in most other mammals. There have been no conclusive tests regarding the treatment on pregnant or lactating cats.

Usage Information

You need to apply the Advantage Multi for Cats to the back of your cat’s neck every 30 days. This will kill any current infestation of fleas and prevent further infestations by interrupting the life cycle of the insect.

You do need to avoid letting your cat clean the treated area for at least 30 minutes. You also need to keep small children away from the cat and not let other cats around the treated animal for the same period of time.


Because this is a prescription only product, there are very few reviews available from the average consumer. Most of the reviews come from veterinarians, and concern which side effects to watch for after the cat has been treated.

There were a few reviews available that spoke of how well the product worked and that it had no detrimental effect on the treated cat. The only bad review was that it does not remove the worms but only prevents future infections, so a deworming treatment had to be purchased along with the Advantage Multi for Cats.

Side Effects and Precautions

The only side effect seems to be irritation and sensitivity in some animals. If your pet shows any adverse symptoms, then you should contact your veterinarian immediately and wash the treated area with warm water and a pet-safe shampoo.

Here is a list of the possible side effects and what to watch for in your cat:

  • Facial swelling
  • Hives
  • Scratching
  • Diarrhea
  • Vomiting
  • Shock
  • Seizures
  • Pale gums
  • Cold limbs
  • Coma


While there appear to be several side effects possible, they appear to be very rare (about one out of every 1,000 cats). This leads us to conclude that, while this product does have more strenuous requirements that must be followed during treatment, it should be safe to use on most cats.

If you have small children, isolating the cat in the bathroom or bedroom during the quarantine period would be advisable, but after the 30 minutes, the cat should be fine as safe around your children and other pets.

We would have to give Advantage Multi thumbs up for function even though there are some serious side effects. Because the complications are so rare, the overall recommendation would be positive due to the effectiveness of this medication.

If you’ve tried Advantage Multi for Cats, please tell us about your experience in the comments section below.

4 Responses to “Advantage Multi for Cats Review”
  1. Gerri says:

    I’ve used advantage multi on cats for awhile. I think it’s great. I even use it on a stray cat that stays right by my home. I love the fact how much it does for my kitties. I’ve never had a problem with it. I just like knowing they are well protected.

  2. Alistair Gilbert says:

    Vet applied Advantage Multi to our cat while boarding. After collecting the cat we noticed patches of fur loss and unsightly red lesions on the skin in two places. The treatment had been applied to the back of the neck. As far as I’m concerned this is a serious side effect and will not use this product again.
    Not sure how it is determined that only one in one thousand cats may be affected. This was the first time Advantage Multi was applied. Previously used Advantage with no problems.

  3. Cat says:

    Just applied Advantage Multi to our two cats (both male, one 8.5 and one about 3) approximately 36 hours ago. Neither showing any adverse reaction. Our vet recommended it when we discovered that our new family member (Jack Russell mix we took in as a stray) has hooks and whips, and is heartworm positive. Glad that we can protect the whole family – seems I hear more and more about heartworms here in the South (US) each summer.

  4. Ron says:

    I love this product. My cat had been through several other treatments including a dip with poor results. Advantage multi worked great. ALL fleas are gone and he is a happy boy!

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