Warning: session_start(): open(/var/lib/php/sessions/sess_8vrjqg88pp0tbrip0fvo5ikos3, O_RDWR) failed: No space left on device (28) in /home/forge/fixfleas.com/public/wp-content/plugins/wp-custom-admin-bar/custom-admin-bar-functions.php on line 8

Warning: session_start(): Failed to read session data: files (path: /var/lib/php/sessions) in /home/forge/fixfleas.com/public/wp-content/plugins/wp-custom-admin-bar/custom-admin-bar-functions.php on line 8
Advantage II Vs Frontline Plus for Dogs and Cats

Advantage II Vs Frontline Plus

Which of these Flea Drops is Best for Your Pet?


Are you trying to find a Spot-on flea treatment that will protect your dog or cat from fleas and other biting parasites?

If so, you’ve probably discovered that there are about a million of them out there, all claiming to do the same thing.

Today we’re going to compare Advantage II and Frontline Plus so that you know what the real differences are in order to find the best flea drop for your dog.

What Do They Do?

Both Frontline Plus and Advantage II have two active ingredients, but they don’t share any. Frontline Plus has fipronil and S-methoprene. Fipronil is a neurotoxin that kills parasites by exciting their nervous systems. It works for fleas, ticks, mites and other biting insects.

S-methoprene is an insect growth inhibitor, which means that it prevents the growth of eggs and larvae so that they never develop into adult insects. In other words, Frontline Plus kills adult insects as well as eggs and larvae.

Frontline Plus claims to work for at least a month and is safe for pregnant and nursing pets.

Advantage II has imidicloprid and pyriproxyfen. Imidicloprid is a neurotoxin that acts similarly to the active ingredient in Frontline Plus. Unlike fipronil, however, imidicloprid is slightly toxic to mammals as well, so make sure that you use it as directed. It is also only effective on fleas and doesn’t kill ticks or other biting insects.

Pyriproxyfen is an IGR similar to S-methoprene and is non-toxic to humans.

Advantage II claims to work for UP TO 30 days and recommends that you consult your vet prior to using on pregnant or nursing animals.

Side Effects Comparison

The side effects are basically the same for Frontline Plus and Advantage II. The main one is skin irritation but rarely, lethargy, confusion, increased whining, and vomiting may occur. As we’ve already stated, Advantage II is slightly more toxic than Frontline II.


Both spot-on flea treatments are available over the counter and kill fleas, flea eggs and larvae. In addition, Frontline Plus also kills ticks and lice and can help prevent mange caused by biting insects.

Advantage II is safe for puppies 7 weeks of age and older and kittens 8 weeks and older. Frontline is good for both kittens and puppies 8 weeks and older.

In our opinion, Frontline Plus edges out Advantage II because of its effective time, the fact that it kills ticks and other biting insects in addition to fleas, and the fact that it’s safe for use on pregnant and nursing animals.

If you’re just looking for a flea drop, then Advantage II may be just fine for you. If you’re in an area where ticks, mites and other biting insects are an issue, we recommend going with Frontline Plus.

To find great deals on Frontline Plus, click here. Otherwise, click here to buy Advantage II for less than you’ll pay at the pet store.

If you’ve used either Frontline Plus or Advantage II or both, please tell us about your experience in the comments section below.

Be the first! Share your experience!

Tell Us What You Think!

Spam protection (register to skip this)

Time limit is exhausted. Please reload the CAPTCHA.