Advantage II for Cats Review

A Flea Drop that Kills Both Fleas & Ticks?


Choosing the right product to help keep your cat flea free can be difficult and we understand. That is why we have compiled all of the information you need to decide if Advantage II for Cats is right for your household.

We’ll share everything from what the company claims to what real users say about the product. We even tell you about the active ingredients and give you some useful information regarding the various warning and side effects of the medication.

Company Claims

Advantage II for Cats is a topical flea medicine that kills adult fleas and prevents the eggs from developing into adults.

It works for a full 30 days, lowering the number of applications needed to keep you pet flea free. It is also waterproof, so you will not have to worry about reapplying when your cat accidently gets wet.

Active Ingredients

The two active ingredients for Advantage II for Cats are:

  • Imidacloprid
  • Pyriproxyfen

How Does Advantage II for Cats Work?

Imidacloprid acts as a neurotoxin in insects, causing them to lose control of their central nervous system. This leads to paralysis and eventual death. It is also slightly toxic to mammals and should only be used on the outside of your pets.

It is one of the most widely used insecticides in the world but it is considered moderately toxic when ingested orally.

Pyriproxyfen is a juvenile hormone analog that prevents insect pupa from developing into adults. It interrupts the life cycle of the fleas by preventing the full development of the insect. It is completely non-toxic to humans and has been shown to have no detrimental effect on other mammals.

Usage Information

You would apply Advantage II for Cats to the back of your cat’s neck once a month. It should be applied at the juncture of the skull and the spine to prevent your car from licking the treated area.

You should avoid washing your cat for 24 hours after application.

What Are Users Saying?

While there are no reports of actual injury from Advantage II for Cats, there are some concerns. It does not appear to work at all on ticks or other parasites, just fleas. If your cat is an indoor/outdoor variety, then you may want to consider another product.

Some reviews have expressed concern because of the warning that tells you to avoid contact with your cat’s eyes and mouth. This makes them nervous because animals often clean themselves with their tongues, especially cats.

There have also been comments regarding cats around small children, who may pet the animal and then put their fingers into their mouth.

Side Effects and Precautions

There are two main precautions mentioned in the directions for Advantage II for Cats. The first is that you should avoid getting the product into your cat’s eyes or mouth.

You should also avoid contact with skin on humans and should contact a poison control center if swallowed. It cannot be used on aged, pregnant or nursing animals.


We’re still giving this product a thumbs up because it does kill fleas like it claims. Because of the various warnings and cautions associated with the active ingredients in Advantage II for Cats, we cannot give it a full recommendation. If your pets are going to be around small children, you definitely want to consider another product.

The warning about avoiding contact with skin on humans also makes us nervous regarding how it is affecting the skin of your cat. There are better alternatives available to kill fleas and many of them will also work on ticks without the problems associated with these pesticides.

If you don’t have small kids or know that your cat won’t react, click here to find a good deal on Advantage II.

If you’ve used Advantage II on your cat, please tell us about your experience in the comments section below.

2 Responses to “Advantage II for Cats Review”
  1. Sarah says:

    Advantage II AND Frontline Plus have problems with effectiveness after using a certain number of years. Fleas are still biting our cats.

  2. rmlb says:

    I purchased the Advantage II for my two indoor cats after using Frontline for many years because I thought it might be a better choice. A day after applying it on both my cats my female vomited a few times during the night and by the next day her eyes were swollen and red and her ears were bright crimson red. I immediately took her to the vet. He gave her a cortisone shot and cortisone medication to take for a week. He felt she might have ingested it somehow. The next morning she was notably better. I can not recommend this product after this experience nor will I be purchasing it again.

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